The spontaneous assembly of amphiphilic bilayer vesicles may serve as model systems that have similarities to modern cellular membranes. These vesicles could grow, divide, and are selectively permeable. They provide compartmentalization and concentrate water soluble species and thus, act as microreactors. The vesicles provide important environments for chemical reactions. For instance, the trans-membrane electron transfer reaction (TM-ETR) across bilayer lipid provides a unique opportunity for the separation of photochemically generated oxidants and reductants. In the first step, photo induced electron-hole pair is formed in the photocatalytic mineral. This electron can pass through a sequence of steps along electron shuttle or molecular wires. Thus, the complete network could perform “protometabolism” (prebiotic energy storage networks) by the use of photochemical energy.